Epidemiology, Clinical Features and Diagnosis of Contrast Induced Nephropathy: A Brief Review

Contrast-Induced Nephropathy (CIN) is defined as acute deterioration of renal function after the administration of radio-contrast materials, mostly within a period of 24 to 48 hours. As we perform more contrast-containing procedures and imaging such as coronary angiography and angioplasty or computed tomography, it is expected that CIN will be increasingly common in our day-to-day practice. CIN is projected to account for 15% of episodes of acute kidney injury occurring in hospital. However, CIN carries a long-lasting adverse impact on patient outcomes rather than transient impairment of volume/electrolytes regulation only. The pathophysiological sequences behind include the tubulotoxicity of contrast per se, the induction of oxidative stress in the renal microenvironment, and the vasoactive properties of contrast materials. Although traditionally serum creatinine is utilized as means of diagnosing CIN, the emergence of new biomarkers and new classification schemes of AKI facilitate earlier diagnosis and planning of strategies to mitigate the influence of CIN. It is of paramount importance for physicians to be aware of the clinical features, courses and means of preventing CIN, so as to reduce the incidence of this potentially avoidable complication. *Corresponding author: Chia-Ter Chao, Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Zhong-Zheng District, Taipei 100, Taiwan, Tel: 886-2-23123456 ext. 63098; Fax: 886-223952333; E-mail: [email protected] Received January 21, 2013; Accepted February 21, 2013; Published February 28, 2013 Citation: Chao CT (2013) Epidemiology, Clinical Features and Diagnosis of Contrast Induced Nephropathy: A Brief Review. Gen Med (Los Angel) 1: 102. doi: 10.4172/2327-5146.1000102 Copyright: © 2013 Chao CT. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.